Cancer Susceptibility Counseling and Decisions (CASCADE)

The primary goal of this research is to test a web-based genetic education intervention
that is designed to educate men and women from hereditary cancer families about the
personal relevance of genetic testing in order to help them male decisions about whether
to pursue genetic testing. We will test this intervention against standard care for men
and women from hereditary cancer families. The web-based educational intervention
includes all of the information typically covered during genetic counseling. As a result,
after completing the education intervention, participants can proceed directly to a brief
telephone call with a genetic counselor followed by testing if they choose. A baseline
survey will be administered prior to randomization and then follow-up surveys will be
administered at 1-month and 6-months post-randomization. Primary outcomes will be
completion of genetic counseling, uptake of genetic testing, genetic test results and
quality of life.

Inclusion Criteria:

- A first- (sibling, adult offspring) or second-degree (aunt/uncle, niece/nephew if
at-risk parent is deceased) biological relative of an individual with a recently
identified BRCA1 or BRCA2 mutation

Exclusion Criteria:

- Personal diagnosis of metastatic cancer

- Prior genetic testing for hereditary breast/ovarian cancer

- Have one or more children who have tested positive for a BRCA1 or BRCA2 mutation

- Cannot participate in or understand English

- Cannot provide meaningful informed consent