A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY FOR LNCB74, A B7-H4 TARGETED ANTIBODY DRUG CONJUGATE, AS MONOTHERAPY IN PARTICIPANTS WITH ADVANCED SOLID TUMORS

This is an open-label, phase 1, dose escalation and dose expansion study to determine
safety and tolerability, and to determine the maximum tolerated dose and / or recommended
phase 2 dose of LNCB74 in participants with advanced solid tumors.

Inclusion Criteria:

1. The participant provides written informed consent

2. ≥ 18 years of age on day of signing informed consent.

3. Participant with histologically or cytologically confirmed diagnosis of advanced
unresectable and/or metastatic solid tumors

4. A male participant must agree to use contraception and refrain from sperm donation
or expecting to father a child

5. A female participant is eligible to participate if she is not pregnant, not
breastfeeding, not a woman of childbearing potential

6. Have measurable disease per RECIST 1.1 as assessed by the local site
investigator/radiology

7. Able to provide tumor tissue sample.

8. Willing to undergo fresh tumor biopsy at Screening and On-treatment if archival
tissue not available

9. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1

10. Life expectancy greater than or equal to 12 weeks as judged by the Investigator.

11. Have adequate organ function

Exclusion Criteria:

1. A WOCBP who has a positive serum pregnancy test (within 72 hours) prior to
treatment.

2. Has received prior investigational agents within 4 weeks prior to treatment.

3. Has received anti-cancer chemotherapy (Immunotherapy (non-antibody-based therapy),
retinoid therapy, hormonal therapy within 2 weeks prior to treatment.

4. Has received antibody-based anti-cancer therapy within 4 weeks prior to treatment.

5. Has received targeted agents and small molecules within 2 weeks or 5 half-lives,
whichever is longer.

6. Has received prior platinum-based chemotherapy and progressed within 4 weeks of
initiating therapy (platinum-refractory disease)

7. Has received an ADC with MMAE payload.

8. Has received prior radiotherapy within 2 weeks of start of study treatment for focal
radiation or within 4 weeks for wide-field radiotherapy

9. Has received G-CSF or GM-CSF within 7 days prior to start of study treatment.

10. Has received a live or live-attenuated vaccine within 30 days prior to the first
dose of study intervention.

11. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to the first dose of study drug

12. Has a known additional malignancy that is progressing or has required active
treatment within the past 3 years

13. Has known active CNS metastases and/or carcinomatous meningitis

14. Has severe hypersensitivity (≥ Grade 3), known allergy or reaction LNCB74 or any of
its excipients.

15. Has a history of (non-infectious) pneumonitis / interstitial lung disease that
required steroids or has current pneumonitis / interstitial lung disease.

16. Has active ≥Grade 2 sensory or motor neuropathy.

17. Has active or chronic corneal disorders, other active ocular conditions requiring
ongoing therapy or any clinically significant corneal disease.

18. Has an active infection requiring systemic therapy.

19. Any major surgery within 4 weeks of study drug administration.

20. Toxicity (except for alopecia) related to prior anti-cancer therapy and/or surgery,
unless the toxicity is either resolved, returned to baseline or Grade 1, or deemed
irreversible.

21. Prior organ or tissue allograft.

22. Uncontrolled or significant cardiovascular disease

23. Participants with serious or uncontrolled medical disorders.

24. Participants who are on total parenteral nutrition (TPN)

25. Participants with history of bowel obstruction within one month of screening

26. Participants with history of significant ascites requiring paracentesis within 2
weeks of screening

27. Has a known history of human immunodeficiency virus (HIV) infection with an acquired
immune deficiency syndrome (AIDS)-defining opportunistic infection within the last
year, or a current CD4 count <350 cells/µl

28. Has known active Hepatitis B (defined as HBsAg reactive) or known active Hepatitis C
virus (defined as HCV RNA [qualitative] is detected) infection

29. Has a history or current evidence of any condition, therapy, or laboratory
abnormality, or other circumstance that might confound the results of the study or
interfere with the participant's participation for the full duration of the study

30. Has a known psychiatric or substance abuse disorder that would interfere with the
participant's ability to cooperate with the requirements of the study