Thejus Jayakrishnan, MD

Dr. Thejus Jayakrishnan is a gastrointestinal medical oncologist at Dana-Farber Cancer Institute and Brigham and Women's Hospital, and an Instructor in Medicine at Harvard Medical School. He earned his medical degree from the All India Institute of Medical Sciences in New Delhi, India, followed by residency training in internal medicine at Allegheny Health Network, Pittsburgh. He completed his medical oncology fellowship at Cleveland Clinic, where he worked closely with Dr. Alok Khorana, a key mentor who helped shape his focus on gastrointestinal oncology.

Dr. Jayakrishnan’s research has uncovered unique metabolic pathway alterations in early-onset colorectal cancer, correlations between plasma metabolomic differences and tumor-associated microbiome in early-onset colorectal cancer, and distinct mutational landscapes in early-onset cholangiocarcinoma. His work has earned multiple ASCO Conquer Cancer Merit Awards and has been published in NPJ Precision Oncology, JCO Precision Oncology, and Nature Scientific Reports. His current research focuses on addressing critical gaps in the understanding of early-onset gastrointestinal cancers through translational research using multi-omic tools, with the goal of developing biomarkers for screening and therapeutic interventions.

In the clinic, Dr. Jayakrishnan treats patients with all types of gastrointestinal cancers and works closely with the Young-Onset Colorectal Cancer Center. He is dedicated to translating his research findings into clinical trials aimed at improving the care and treatment outcomes for individuals with gastrointestinal cancers globally.